Heterocyclic Compounds as Inflammation Inhibitors

Author(s): Sham M. Sondhi, Nidhi Singhl, Monika Johar, B.S. Narayan Reddy, J. William Lown.

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 10 , 2002

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Abstract:

Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with significant toxicity particularly in the gastrointestinal tract and kidney. Various approaches such as formulation & co-administration (of agents to protect the stomach), chemical manipulation and synthesis of new safer anti-inflammatory drugs reported in the literature to overcome the toxicity of NSAIDs have been summarized. As far as synthesis of new more effective and safer anti-inflammatory drugs is concerned, we have reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidines, imidazole, benzimidazole, thiazole, thiazolidine, acridine, thiourea, alkanoic acid derivatives and other related heterocyclic compounds and their role as inflammation inhibitors.

Keywords: Heterocyclic compounds, Inflammation inhibitors, nonsteroidal

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Article Details

VOLUME: 9
ISSUE: 10
Year: 2002
Page: [1045 - 1074]
Pages: 30
DOI: 10.2174/0929867024606678
Price: $58

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