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Author(s): Philip Hajduk.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 8 , 2002

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Abstract:

Philip Hajduk did his undergraduate work at the University of Illinois - Urbana, where he received a B.S. in Chemistry in 1989. He completed his graduate work under the supervision of Prof. Laura Lerner at the University of Wisconsin – Madison, where he received his Ph.D. in Chemistry in 1993. He then began work as a post-doctoral fellow at Abbott Laboratories under Dr. Stephen Fesik, and was converted to Staff Scientist in 1996. Dr. Hajduk currently heads the NMR-based screening group at Abbott. The research interests of Dr. Hajduk include many aspects of drug discovery and design, with special emphasis on the application of NMR spectroscopy to enable and expedite the process. He was involved in the early development and application of SAR by NMR™ , and continues to investigate the utility of fragment-based approaches to drug discovery. Some recent publications are listed below. Dr. Hajduk currently lives with his wife, Kathleen, and two children, Jason and Allison, in Mundelein, IL. As a committed Christian, Phil is thankful for the opportunity to be engaged in pharmaceutical research that is exciting, fulfilling, and has the potential to positively impact many people. Soli Deo Gloria. Mao, H.; Hajduk, P.J.; Craig, R.; Bell, R.; Borre, T.; Fesik, S.W. “Rational Design of Diflunisal Analogs with Reduced Affinity for Human Serum Albumin.” J. Am. Chem. Soc., 123 (43), 10429-10435 (2001). Hajduk, P. J.; Gomtsyan, A.; Didomenico, S.; Cowart, M.; Bayburt, E. K.; Solomon, L.; Severin; Smith, R.; Walter, K.; Holzman, T. F.; Stewart, A.; McGaraughty, S.; Jarvis, M. F.; Kowaluk, E. S.; Fesik, S. W. “Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments.” J. Med. Chem 43, 4781-4786 (2000). Hajduk, P. J.; Boyd, S.; Nettesheim, D.; Nienaber, V.; Severin, J.; Smith, R.; Davidson, D.; Rockway, T.; Fesik, S. W. “The Identification of Novel Inhibitors of Urokinase Using NMR-Based Screening.” J. Med. Chem. 43, 3862-3866 (2000). Hajduk, P.J.; Bures, M.; Praestgaard, J.; Fesik, S.W. “Privileged Molecules for Protein Binding Identified from NMR-Based Screening.” J. Med. Chem. 43(18), 3443-3447 (2000). Hajduk, P. J.; Augeri, D. A.; Mack, J.; Mendoza, R.; Yang, J.; Betz, S. F.; Fesik, S. W. “NMR-Based Screening of Proteins Containing 13C-Labeled Methyl Groups.” J. Med. Chem. 122, 7898-7904 (2000).

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Article Details

VOLUME: 5
ISSUE: 8
Year: 2002
Page: [663 - 663]
Pages: 1
DOI: 10.2174/1386207023329969

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