Abstract
Cancer is the result of cumulative multiple genetic mutations, which result in the activation of oncogenes and / or the inactivation of tumor suppressor genes. Current theories of malignant transformation postulate that the development of primary brain tumors is the consequence of the sequential accumulation of multiple genetic alterations in brain cells, each of which contributes to the induction of a progressively more malignant phenotype. Traditionally, our understanding of brain tumor biology has come from the study of single specific genes or chromosome regions at a time. Although several genetic aberrations and gene expression changes have been identified using such focused techniques, the traditional methods of cancer research are tediously slow and provide limited insight into the global gene expression patterns that occur during the malignant transformation, development, and progression of primary brain cancers. Because hundreds of genes may be simultaneously involved in the mechanisms of ca rcinogenesis, new genomic high-throughput technologies have recently come into the forefront of cancer research. These technologies, which include cDNA and oligonucleotide microarrays (gene chips) and tissue microarray (tissue chip) techniques, may considerably facilitate the molecular profiling of human tumors. Such molecular fingerprinting of malignant gliomas, for example, may lead to advances in diagnosis, prognosis, and design of novel therapeutic approaches that could improve the clinical outcome of patients suffering from this rapidly fatal disease. This review will describe the principles of microarray technology as applied to human brain tumor research, summarize its use and limitations in identifying brain tumor-associated genes thus far, and speculate on the future applications and clinical ramifications of such genomic large-scale screening techniques in neuro-oncology.
Keywords: Microarrays, Brain Tumors, cancer, cdna microarrays, tissue microarray tma analysis, insulin-like growth, protein2 1gfbp2, facetor binding gene
Current Genomics
Title: Microarrays and the Genetic Analysis of Brain Tumors
Volume: 3 Issue: 1
Author(s): L. M. Liau and I. Yang
Affiliation:
Keywords: Microarrays, Brain Tumors, cancer, cdna microarrays, tissue microarray tma analysis, insulin-like growth, protein2 1gfbp2, facetor binding gene
Abstract: Cancer is the result of cumulative multiple genetic mutations, which result in the activation of oncogenes and / or the inactivation of tumor suppressor genes. Current theories of malignant transformation postulate that the development of primary brain tumors is the consequence of the sequential accumulation of multiple genetic alterations in brain cells, each of which contributes to the induction of a progressively more malignant phenotype. Traditionally, our understanding of brain tumor biology has come from the study of single specific genes or chromosome regions at a time. Although several genetic aberrations and gene expression changes have been identified using such focused techniques, the traditional methods of cancer research are tediously slow and provide limited insight into the global gene expression patterns that occur during the malignant transformation, development, and progression of primary brain cancers. Because hundreds of genes may be simultaneously involved in the mechanisms of ca rcinogenesis, new genomic high-throughput technologies have recently come into the forefront of cancer research. These technologies, which include cDNA and oligonucleotide microarrays (gene chips) and tissue microarray (tissue chip) techniques, may considerably facilitate the molecular profiling of human tumors. Such molecular fingerprinting of malignant gliomas, for example, may lead to advances in diagnosis, prognosis, and design of novel therapeutic approaches that could improve the clinical outcome of patients suffering from this rapidly fatal disease. This review will describe the principles of microarray technology as applied to human brain tumor research, summarize its use and limitations in identifying brain tumor-associated genes thus far, and speculate on the future applications and clinical ramifications of such genomic large-scale screening techniques in neuro-oncology.
Export Options
About this article
Cite this article as:
Liau M. L. and Yang I., Microarrays and the Genetic Analysis of Brain Tumors, Current Genomics 2002; 3 (1) . https://dx.doi.org/10.2174/1389202023350633
DOI https://dx.doi.org/10.2174/1389202023350633 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Radioprotective Effects of Plants from the Lamiaceae Family
Anti-Cancer Agents in Medicinal Chemistry CD147/EMMPRIN and CD44 are Potential Therapeutic Targets for Metastatic Prostate Cancer
Current Cancer Drug Targets Drugs for AIDS
Mini-Reviews in Medicinal Chemistry Transferrin Coupled Liposomes for Enhanced Brain Delivery of Doxorubicin
Vascular Disease Prevention (Discontinued) Imaging of Hypoxia Using PET and MRI
Current Pharmaceutical Biotechnology Anticancer Peptides and Proteins: A Panoramic View
Protein & Peptide Letters Discovery of Small Molecules that Target Autophagy for Cancer Treatment
Current Medicinal Chemistry The Function and Regulation of BMP6 in Various Kinds of Stem Cells
Current Pharmaceutical Design The Expression, Function and Targeting of Haem Oxygenase-1 in Cancer
Current Cancer Drug Targets Small Molecule CXCR4 Chemokine Receptor Antagonists: Developing Drug Candidates
Current Medicinal Chemistry GRP78 Influences Chemoresistance and Prognosis in Cancer
Current Drug Targets Micro-/Nano-Scale Biointerfaces, Mechanical Coupling and Cancer Therapy
Current Topics in Medicinal Chemistry OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease
Current Immunology Reviews (Discontinued) Patents in Cancer Stem Cells
Recent Patents on Biomarkers Presynaptic Cell Dependent Modulation of Inhibition in Cortical Regions
Current Neuropharmacology Autophagy : Moving Benchside Promises to Patient Bedsides
Current Cancer Drug Targets Prophylactic Admission of an In Vitro Reconstructed Complexes of Human Recombinant Heat Shock Proteins and Melanoma Antigenic Peptides Activates Anti-Melanoma Responses in Mice
Current Molecular Medicine Cancer Cell Reprogramming: Stem Cell Differentiation Stage Factors and An Agent Based Model to Optimize Cancer Treatment
Current Pharmaceutical Biotechnology Network Pharmacology and Reverse Molecular Docking-Based Prediction of the Molecular Targets and Pathways for Avicularin Against Cancer
Combinatorial Chemistry & High Throughput Screening Environmental Risk Assessment of Replication Competent Viral Vectors Applied in Clinical Trials: Potential Effects of Inserted Sequences
Current Gene Therapy