Bcl-2-Related Proteins as Drug Targets

Author(s): Jason W. O'Neill, David M. Hockenbery.

Journal Name: Current Medicinal Chemistry

Volume 10 , Issue 16 , 2003

Abstract:

The Bcl-2 family of proteins provide the most unambiguous link between mitochondrial functions and apoptosis, as their only (or principal) functions appear to be as regulators of this cell death pathway. Rational drug design to manipulate the functions of these proteins has been hampered by the lack of a clear understanding of a biochemical or molecular function, with disruption of intra-family protein-protein interactions as the only known, but daunting, objective. There has been substantial progress in this task using molecular modeling and drug leads. The prospects are also good for development of chemical tools for functional analysis of the Bcl-2 proteins.

Keywords: bcl-2-related proteins, bcl-2 family, apoptosis, intra-family protein-protein, chemical tools, bcl-2 proteins

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Article Details

VOLUME: 10
ISSUE: 16
Year: 2003
Page: [1553 - 1562]
Pages: 10
DOI: 10.2174/0929867033457241
Price: $58

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