Abstract
The Bcl-2 family of proteins provide the most unambiguous link between mitochondrial functions and apoptosis, as their only (or principal) functions appear to be as regulators of this cell death pathway. Rational drug design to manipulate the functions of these proteins has been hampered by the lack of a clear understanding of a biochemical or molecular function, with disruption of intra-family protein-protein interactions as the only known, but daunting, objective. There has been substantial progress in this task using molecular modeling and drug leads. The prospects are also good for development of chemical tools for functional analysis of the Bcl-2 proteins.
Keywords: bcl-2-related proteins, bcl-2 family, apoptosis, intra-family protein-protein, chemical tools, bcl-2 proteins
Current Medicinal Chemistry
Title: Bcl-2-Related Proteins as Drug Targets
Volume: 10 Issue: 16
Author(s): Jason W. O'Neill and David M. Hockenbery
Affiliation:
Keywords: bcl-2-related proteins, bcl-2 family, apoptosis, intra-family protein-protein, chemical tools, bcl-2 proteins
Abstract: The Bcl-2 family of proteins provide the most unambiguous link between mitochondrial functions and apoptosis, as their only (or principal) functions appear to be as regulators of this cell death pathway. Rational drug design to manipulate the functions of these proteins has been hampered by the lack of a clear understanding of a biochemical or molecular function, with disruption of intra-family protein-protein interactions as the only known, but daunting, objective. There has been substantial progress in this task using molecular modeling and drug leads. The prospects are also good for development of chemical tools for functional analysis of the Bcl-2 proteins.
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Cite this article as:
O'Neill W. Jason and Hockenbery M. David, Bcl-2-Related Proteins as Drug Targets, Current Medicinal Chemistry 2003; 10 (16) . https://dx.doi.org/10.2174/0929867033457241
DOI https://dx.doi.org/10.2174/0929867033457241 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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