The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death
David J. Granville and Roberta A. Gottlieb
Affiliation: Department of Molecularand Experimental Medicine, 10550 North Torrey Pines Road, La Jolla,CA, 92037, USA.
Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.
Keywords: mitochondria, apoptosis, vdac, heart, cytochrome c, cell death
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