Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer

Author(s): Jason D. Jacintho, Peter Kovacic.

Journal Name:Current Medicinal Chemistry

Volume 10 , Issue 24 , 2003


This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.

Keywords: nitric oxide, catecholamines, glutamate, neurotransmission, neurotoxicity, oxidative stress, reactive oxygen species

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Article Details

Year: 2003
Page: [2693 - 2703]
Pages: 11
DOI: 10.2174/0929867033456404
Price: $58