Abstract
Chemical genomics represents a cooperation of biology and chemistry to identify and intervene the biological targets. Small molecules with diverse structural characteristics should be used to validate the target through interfering with the biological processes. Because of the limitation of existing chemical libraries, the diversity can be exploited using both the molecular design techniques; structure-based design and ligand-based design. These methods can guide the selection of small molecules with optimal binding properties to desired biological targets. Studies of potential molecular targets for novel anticancer drug discovery including in silico screening, QSAR, and de novo design demonstrated the importance of chemical genomics strategy to find the chemical probes and drug lead compounds.
Keywords: Chemical Genomics, Anticancer Agents, silico screening
Current Medicinal Chemistry
Title: Chemical Genomics Strategy for the Discovery of New Anticancer Agents
Volume: 10 Issue: 9
Author(s): Mankil Jung, Hanjo Kim and Myosun Kim
Affiliation:
Keywords: Chemical Genomics, Anticancer Agents, silico screening
Abstract: Chemical genomics represents a cooperation of biology and chemistry to identify and intervene the biological targets. Small molecules with diverse structural characteristics should be used to validate the target through interfering with the biological processes. Because of the limitation of existing chemical libraries, the diversity can be exploited using both the molecular design techniques; structure-based design and ligand-based design. These methods can guide the selection of small molecules with optimal binding properties to desired biological targets. Studies of potential molecular targets for novel anticancer drug discovery including in silico screening, QSAR, and de novo design demonstrated the importance of chemical genomics strategy to find the chemical probes and drug lead compounds.
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Cite this article as:
Jung Mankil, Kim Hanjo and Kim Myosun, Chemical Genomics Strategy for the Discovery of New Anticancer Agents, Current Medicinal Chemistry 2003; 10 (9) . https://dx.doi.org/10.2174/0929867033457782
DOI https://dx.doi.org/10.2174/0929867033457782 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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