Oligonucleotide-Based Molecular Therapy for Restenosis after Angioplasty

Author(s): Motokuni Aoki, Ryuichi Morishita, Toshio Ogihara.

Journal Name: Current Drug Targets

Volume 4 , Issue 8 , 2003

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Abstract:

Molecular therapy is emerging as a potential strategy for the treatment of cardiovascular disease such as restenosis after angioplasty, vascular bypass graft occlusion, transplant coronary vasculopathy, homozygous familial hypercholesterolemia and cystic fibrosis, for which no known effective therapy exists. Molecular biology and pathophysiology of the cardiovascular system have started to emerge, and the time is ripe for the introduction of gene therapy to the management of cardiovascular disorders. In this review, we have focused on the future potential of oligonucleotide-based gene therapy for restenosis after angioplasty, which still remains an issue in the field of cardiovascular disease.

Keywords: gene therapy, antisense, ribozyme, cis-element decoy, restenosis, e2f

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Article Details

VOLUME: 4
ISSUE: 8
Year: 2003
Page: [613 - 618]
Pages: 6
DOI: 10.2174/1389450033490830
Price: $58

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