Design of β-turn Based Therapeutic Agents

Author(s): K. Kee Suat , Seetharama D.S. Jois .

Journal Name: Current Pharmaceutical Design

Volume 9 , Issue 15 , 2003

Abstract:

Peptides and proteins are essential to many biological processes. The interaction between the peptide ligands and their receptor targets commonly involves β-turn structures. Yet poor bioavailability and unfavorable pharmacokinetics significantly compromise the use of peptides as drugs. Thus, there has been a great deal of interest in the design of peptidomimetics (modified peptides) as therapeutic agents by mimicking β-turn structures. This review highlights the importance of β-turn in the design of various peptidomimetics for many diseases. This review also outlines several β-turn mimicking strategies and its application in the design of potent peptide analogues. β-turn mimetics often tend to be more rigid in positioning the critically important amino acid residues and thus optimize the surface conformation for productive interaction with the receptors.

Keywords: proteins, peptidomimetics, amino acid, pharmacokinetics, melanocyte-stimulating hormone, bradykinin, lutenizing, circular dichroism(cd)

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Article Details

VOLUME: 9
ISSUE: 15
Year: 2003
Page: [1209 - 1224]
Pages: 16
DOI: 10.2174/1381612033454900
Price: $58

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