Abstract
The healing of gastric ulcer is a complicated process that involves the proliferation of epithelial and endothelial cells and the concerted actions of a wide range of growth factors. Prostaglandins play an important role in ulcer healing. Expression of cyclooxygenase-2 (COX-2) is markedly upregulated around the margins of gastric ulcers and its inhibition leads to a delay of ulcer healing. Several of the growth factors that promote ulcer healing may work in part through COX- 2-dependent mechanisms. Angiogenesis, which is crucial to ulcer healing, is tightly regulated by growth factors. Treatment with selective COX-2 inhibitors appears to alter the balance of serum levels of growth factors, favoring an inhibition of angiogenesis. Given the importance of COX-2 in regulating ulcer healing, caution should be taken in the use of selective inhibitors of COX-2 by patients at risk of ulcer disease.
Keywords: ulcer healing, angiogenesis, cyclooxygenase, prostaglandin, endothelium, platelets
Current Pharmaceutical Design
Title: Mucosal Repair and COX-2 Inhibition
Volume: 9 Issue: 27
Author(s): Rafael F. Perini, Li Ma and John L. Wallace
Affiliation:
Keywords: ulcer healing, angiogenesis, cyclooxygenase, prostaglandin, endothelium, platelets
Abstract: The healing of gastric ulcer is a complicated process that involves the proliferation of epithelial and endothelial cells and the concerted actions of a wide range of growth factors. Prostaglandins play an important role in ulcer healing. Expression of cyclooxygenase-2 (COX-2) is markedly upregulated around the margins of gastric ulcers and its inhibition leads to a delay of ulcer healing. Several of the growth factors that promote ulcer healing may work in part through COX- 2-dependent mechanisms. Angiogenesis, which is crucial to ulcer healing, is tightly regulated by growth factors. Treatment with selective COX-2 inhibitors appears to alter the balance of serum levels of growth factors, favoring an inhibition of angiogenesis. Given the importance of COX-2 in regulating ulcer healing, caution should be taken in the use of selective inhibitors of COX-2 by patients at risk of ulcer disease.
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Cite this article as:
Perini F. Rafael, Ma Li and Wallace L. John, Mucosal Repair and COX-2 Inhibition, Current Pharmaceutical Design 2003; 9 (27) . https://dx.doi.org/10.2174/1381612033454027
DOI https://dx.doi.org/10.2174/1381612033454027 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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