Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Folate and Homocysteine Metabolism: Therapeutic Targets in Cardiovascular and Neurodegenerative Disorders

Author(s): Mark P. Mattson and Frank Haberman

Affiliation: Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center,5600 Nathan Shock Drive, Baltimore, MD 21224 USA.

Keywords: apoptosis, atherosclerosis, dietary folic acid, schizophrenia, stem cells

Abstract:

Individuals with elevated homocysteine levels are at increased risk for cardiovascular disease and stroke, and neurodegenerative disorders such as Alzheimers and Parkinsons diseases Homocysteine is a modified form of the amino acid methionine that is tightly regulated by enzymes requiring folate. By impairing DNA repair mechanisms and inducing oxidative stress, homocysteine can cause the dysfunction or death of cells in the cardiovascular and nervous systems. Dietary folate stimulates homocysteine removal and may thereby protect cells against disease processes. The enzymes involved in homocysteine and folate metabolism provide novel targets for drug discovery.

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Article Details

VOLUME: 10
ISSUE: 19
Page: [1923 - 1929]
Pages: 7
DOI: 10.2174/0929867033456864