Abstract
Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release of virion progeny, respectively. The receptor for haemagglutinin is the terminal sialic acid residue of host cell surface sialyloligosaccharides, while sialidase catalyses the hydrolysis of terminal sialic acid residues from sialyloligosaccharides. Extensive crystallographic studies of both these proteins have revealed that the residues that interact with the sialic acid are strictly conserved. Therefore, these proteins make attractive targets for the design of drugs to halt the progression of the virus. Recent successful efforts in the search for new cures for influenza have led to the development of three clinically-useful anti-influenza drugs. All three are potent, selective inhibitors of influenza virus A and B sialidase. Strategies for the development of haemagglutinin inhibitors have also been devised.
Keywords: anti-influenza therapies, Influenza, influenza virus, haemagglutinin inhibitors
Current Drug Targets
Title: Recent Strategies in the Search for New Anti-Influenza Therapies
Volume: 4 Issue: 5
Author(s): J. C. Wilson and M. von Itzstein
Affiliation:
Keywords: anti-influenza therapies, Influenza, influenza virus, haemagglutinin inhibitors
Abstract: Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release of virion progeny, respectively. The receptor for haemagglutinin is the terminal sialic acid residue of host cell surface sialyloligosaccharides, while sialidase catalyses the hydrolysis of terminal sialic acid residues from sialyloligosaccharides. Extensive crystallographic studies of both these proteins have revealed that the residues that interact with the sialic acid are strictly conserved. Therefore, these proteins make attractive targets for the design of drugs to halt the progression of the virus. Recent successful efforts in the search for new cures for influenza have led to the development of three clinically-useful anti-influenza drugs. All three are potent, selective inhibitors of influenza virus A and B sialidase. Strategies for the development of haemagglutinin inhibitors have also been devised.
Export Options
About this article
Cite this article as:
Wilson C. J. and Itzstein von M., Recent Strategies in the Search for New Anti-Influenza Therapies, Current Drug Targets 2003; 4 (5) . https://dx.doi.org/10.2174/1389450033491019
DOI https://dx.doi.org/10.2174/1389450033491019 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Antimitotic Activity on Sea Urchin Embryonic Cells of Seven Antiparasitic Morita-Baylis-Hillman Adducts: A Potential New Class of Anticancer Drugs
Medicinal Chemistry Counter-Regulatory Renin-Angiotensin System: An Important Line of Research to Understand and Limit the Severity of COVID-19
Infectious Disorders - Drug Targets Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies
Current Drug Targets Discovery Strategies in a BioPharmaceutical Startup: Maximising your Chances of Success Using Computational Filters
Current Pharmaceutical Design FDG-PET Scan in Sarcoidosis: Clinical and Imaging Indications
Current Medical Imaging Current Treatments and Therapeutic Options for COVID-19 Patients: A Systematic Review
Infectious Disorders - Drug Targets Molecular Recognition of Ligands in Dipeptidyl Peptidase IV
Current Topics in Medicinal Chemistry Synthesis of A/B-Ring Partial Analogs of Bruceantin as Potential Antimalarial Agents
Medicinal Chemistry Theoretical Study of the Molecular Mechanism of Maxingyigan Decoction Against COVID-19: Network Pharmacology-based Strategy
Combinatorial Chemistry & High Throughput Screening Development of Specific Radiopharmaceuticals for Infection Imaging by Targeting Infectious Micro-organisms
Current Pharmaceutical Design Marine Natural Products as a Source of Drug Leads against Respiratory Viruses: Structural and Bioactive Diversity
Current Medicinal Chemistry Recent Patents in Exhaust Heat Recovery Units
Recent Patents on Mechanical Engineering Allosteric Modulators of Class B G-Protein-Coupled Receptors
Current Neuropharmacology Chloroquine Analogs: An Overview of Natural and Synthetic Quinolines as Broad Spectrum Antiviral Agents
Current Pharmaceutical Design Off-Label Trazodone Prescription: Evidence, Benefits and Risks
Current Pharmaceutical Design Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids
Letters in Drug Design & Discovery Improving the Classification of Nuclear Receptors with Feature Selection
Protein & Peptide Letters The Histamine H4 Receptor and Potential Therapeutic Uses for H4 Ligands
Mini-Reviews in Medicinal Chemistry Sphingolipid Modulation: A Strategy for Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Benzocoumarins: Isolation, Synthesis, and Biological Activities
Mini-Reviews in Medicinal Chemistry