Purification Strategies for Combinatorial and Parallel Chemistry

Author(s): Paul J. Edwards.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 6 , Issue 1 , 2003

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Abstract:

This review surveys the methods developed for the purification of intermediates and final compounds originating from parallel and combinatorial chemistry. Included will be reviews of polymerassisted purification, liquid-phase combinatorial chemistry, fluorous synthesis, liquid-liquid and solid-phase extraction, reverse-phase HPLC and supercritical fluid chromatography. A critique of each method is given, highlighting the methodologies strengths and weaknesses.

Keywords: fluorous synthesis, combinatorial chemistry, parallel chemistry, puriffication strategy, liquid-phase combinatorial chemistry

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2003
Page: [11 - 27]
Pages: 17
DOI: 10.2174/1386207033329832

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