Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
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Cytokine Antibody Arrays: A Promising Tool to Identify Molecular Targets for Drug Discovery

Author(s): Ruo-Pan Huang.

Abstract:

Cytokines play important roles in normal cell functions and changes in cytokines have been implicated in many diseases. Recent efforts have focused on developing cytokine antibody arrays. These arrays allow investigators to simultaneously detect multiple cytokines in qualitative and quantitative ways. Cytokine antibody array systems feature high sensitivity, specificity and throughput. This novel technology opens up an expanding spectrum of applications in drug discovery, including target discovery, target validation, screening for lead compounds, compound optimization and clinical trials.

Keywords: cytokine, protein arrays, antibody arrays, proteomics, expression, drug discovery

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2003
Page: [769 - 775]
Pages: 7
DOI: 10.2174/138620703771826946
Price: $58