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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
VOLUME: 6
ISSUE: 8
DOI: 10.2174/138620703771826946      Price:  $58









Cytokine Antibody Arrays: A Promising Tool to Identify Molecular Targets for Drug Discovery

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Author(s): Ruo-Pan Huang
Pages 769-775 (7)
Abstract:
Cytokines play important roles in normal cell functions and changes in cytokines have been implicated in many diseases. Recent efforts have focused on developing cytokine antibody arrays. These arrays allow investigators to simultaneously detect multiple cytokines in qualitative and quantitative ways. Cytokine antibody array systems feature high sensitivity, specificity and throughput. This novel technology opens up an expanding spectrum of applications in drug discovery, including target discovery, target validation, screening for lead compounds, compound optimization and clinical trials.
Keywords:
cytokine, protein arrays, antibody arrays, proteomics, expression, drug discovery
Affiliation:
Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Woodruff Memorial Research Building Rm. 4219, 1639 Pierce Drive, Atlanta, GA 30322, USA.