Microbial / Enzymatic Synthesis of Chiral Intermediates for Pharmaceuticals: Case Studies from BMS

Author(s): Ramesh N. Patel.

Journal Name: Current Organic Chemistry

Volume 7 , Issue 13 , 2003

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Abstract:

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand from pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial / enzymatic processes mainly taken from the research carried out at BMS have been described for the synthesis of chiral intermediates for antihypertensive drugs, anticholesterol drugs, anticancer agents, antiviral agents, β3-receptor receptor agonists, melatonin receptor agonists, and anti-Alzheimers drugs.

Keywords: melatonin, Alzheimer, enatioselective manner

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Article Details

VOLUME: 7
ISSUE: 13
Year: 2003
Page: [1369 - 1386]
Pages: 18
DOI: 10.2174/1385272033486495
Price: $58

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