Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Tumor Escape from Immune Response: Mechanisms and Targets of Activity

Author(s): Dmitry Gabrilovich and Vladimir Pisarev

Affiliation: H. Lee Moffitt Cancer Center, University of South Florida, MRC-2E, Room 2067, 12902 MagnoliaDr.Tampa, FL, 33612, USA.

Abstract:

Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.

Keywords: Immune, tumor cells, antigen-presenting cells

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Article Details

VOLUME: 4
ISSUE: 7
Page: [525 - 536]
Pages: 12
DOI: 10.2174/1389450033490849
Price: $58