Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Tumor Escape from Immune Response: Mechanisms and Targets of Activity

Author(s): Dmitry Gabrilovich and Vladimir Pisarev

Affiliation: H. Lee Moffitt Cancer Center, University of South Florida, MRC-2E, Room 2067, 12902 MagnoliaDr.Tampa, FL, 33612, USA.


Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.

Keywords: Immune, tumor cells, antigen-presenting cells

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Article Details

Page: [525 - 536]
Pages: 12
DOI: 10.2174/1389450033490849
Price: $58