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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
VOLUME: 6
ISSUE: 2
DOI: 10.2174/1386207033329760      Price:  $58









Metal-Enhanced Fluorescence: Potential Applications in HTS

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Author(s): Chris D. Geddes, Ignacy Gryczynski, Joanna Malicka, Zygmunt Gryczynski and Joseph R. Lakowicz
Pages 109-117 (9)
Abstract:
Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.
Keywords:
Metal-Enhanced, Fluorescence, photostability, biochemical species
Affiliation:
Center for Fluorescence Spectroscopy and Institute of Fluorescence, University of Maryland Biotechnology Institute, Medical Biotechnology Center, 725 West Lombard Street, Baltimore, Maryland 21201, USA