Metal-Enhanced Fluorescence: Potential Applications in HTS

Chris   D.   Geddes; Ignacy      Gryczynski; Joanna      Malicka; Zygmunt      Gryczynski; Joseph   R.   Lakowicz

Abstract

Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.

Keywords: Metal-Enhanced, Fluorescence, photostability, biochemical species

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Combinatorial Chemistry & High Throughput Screening

Title: Metal-Enhanced Fluorescence: Potential Applications in HTS

Volume: 6 Issue: 2

Author(s): Chris D. Geddes, Ignacy Gryczynski, Joanna Malicka, Zygmunt Gryczynski and Joseph R. Lakowicz

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Keywords: Metal-Enhanced, Fluorescence, photostability, biochemical species

Abstract: Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.

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Geddes D. Chris, Gryczynski Ignacy, Malicka Joanna, Gryczynski Zygmunt and Lakowicz R. Joseph, Metal-Enhanced Fluorescence: Potential Applications in HTS, Combinatorial Chemistry & High Throughput Screening 2003; 6 (2) . https://dx.doi.org/10.2174/1386207033329760

DOI https://dx.doi.org/10.2174/1386207033329760	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402

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