Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
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Metal-Enhanced Fluorescence: Potential Applications in HTS

Author(s): Chris D. Geddes, Ignacy Gryczynski, Joanna Malicka, Zygmunt Gryczynski and Joseph R. Lakowicz

Affiliation: Center for Fluorescence Spectroscopy and Institute of Fluorescence, University of Maryland Biotechnology Institute, Medical Biotechnology Center, 725 West Lombard Street, Baltimore, Maryland 21201, USA


Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.

Keywords: Metal-Enhanced, Fluorescence, photostability, biochemical species

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Article Details

Page: [109 - 117]
Pages: 9
DOI: 10.2174/1386207033329760