Abstract
Major aspects of the synthetic utility of 1,3-diketones are reviewed with special emphasis being placed on the regioselectivity of the transformations. The unsymmetrical 1,3-diketone moiety may contain up to five nucleophilic and two electrophilic centers that may only slightly differ in reactivity; therefore, it seems almost impossible to carry out chemical transformations with substrate selectively at only one specific center. However, in many cases it is possible, and in the present review answers to this question as well as many other useful synthetic applications of 1,3-diketones for the construction of carbocycles and heterocycles, and their modern implication in enantioselective, combinatorial, solid phase, and multistep organic syntheses are summarized.
Keywords: 1,3-Diketones, Synthetic Applications, regioselectivity, chemical transformations
Current Organic Chemistry
Title: Recent Advances in the Chemistry of 1,3-Diketones: Structural Modifications and Synthetic Applications
Volume: 7 Issue: 18
Author(s): Alexander V. Kel'in and Andrew Maioli
Affiliation:
Keywords: 1,3-Diketones, Synthetic Applications, regioselectivity, chemical transformations
Abstract: Major aspects of the synthetic utility of 1,3-diketones are reviewed with special emphasis being placed on the regioselectivity of the transformations. The unsymmetrical 1,3-diketone moiety may contain up to five nucleophilic and two electrophilic centers that may only slightly differ in reactivity; therefore, it seems almost impossible to carry out chemical transformations with substrate selectively at only one specific center. However, in many cases it is possible, and in the present review answers to this question as well as many other useful synthetic applications of 1,3-diketones for the construction of carbocycles and heterocycles, and their modern implication in enantioselective, combinatorial, solid phase, and multistep organic syntheses are summarized.
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Cite this article as:
Kel'in V. Alexander and Maioli Andrew, Recent Advances in the Chemistry of 1,3-Diketones: Structural Modifications and Synthetic Applications, Current Organic Chemistry 2003; 7 (18) . https://dx.doi.org/10.2174/1385272033486134
DOI https://dx.doi.org/10.2174/1385272033486134 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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