Abstract
Though sulfur-containing heterocyclic compound syntheses have been extensively studied, syntheses of selenium analogues have not been appreciably investigated. Recently, however, reports of selenium-containing heterocyclic compound synthesis have gradually increased not only because of their interesting reactivities but also because of their pharmaceutical applications. For example, 1,3-selenazines showed significant anti-bacterial activity against both Gram-negative and Gram-positive bacteria and potential anti-tumor effects against several kinds of human cancer cell lines. Selenazofurin (2-β-D-ribofuranosylselenazole-4-carboxamide) demonstrated significant anti-tumor properties in animals and broad spectrum antiviral activity in cell culture experiments. Selenoureas and selenoamides have been used as the precursors for the most of the syntheses of 1,3-selenazines and 1,3-selenazoles. This review article summarizes the recent progress in the development of the synthesis methods of 1,3-selenazine and 1,3-selenazole and their biological significances.
Keywords: 1,3-selenazine, 1,3-selenazole, sulfur-containing heterocyclic compound, selenazofurin, selenoureas, selenoamides
Current Organic Chemistry
Title: Synthesis of 1,3-Selenazine and 1,3-Selenazole and Their Biological Activities
Volume: 7 Issue: 2
Author(s): M. Koketsu and H. Ishihara
Affiliation:
Keywords: 1,3-selenazine, 1,3-selenazole, sulfur-containing heterocyclic compound, selenazofurin, selenoureas, selenoamides
Abstract: Though sulfur-containing heterocyclic compound syntheses have been extensively studied, syntheses of selenium analogues have not been appreciably investigated. Recently, however, reports of selenium-containing heterocyclic compound synthesis have gradually increased not only because of their interesting reactivities but also because of their pharmaceutical applications. For example, 1,3-selenazines showed significant anti-bacterial activity against both Gram-negative and Gram-positive bacteria and potential anti-tumor effects against several kinds of human cancer cell lines. Selenazofurin (2-β-D-ribofuranosylselenazole-4-carboxamide) demonstrated significant anti-tumor properties in animals and broad spectrum antiviral activity in cell culture experiments. Selenoureas and selenoamides have been used as the precursors for the most of the syntheses of 1,3-selenazines and 1,3-selenazoles. This review article summarizes the recent progress in the development of the synthesis methods of 1,3-selenazine and 1,3-selenazole and their biological significances.
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Cite this article as:
Koketsu M. and Ishihara H., Synthesis of 1,3-Selenazine and 1,3-Selenazole and Their Biological Activities, Current Organic Chemistry 2003; 7 (2) . https://dx.doi.org/10.2174/1385272033373102
DOI https://dx.doi.org/10.2174/1385272033373102 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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