Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Modified Envelope Glycoproteins to Retarget Retroviral Vectors

Author(s): Catherine Haynes, Otto Erlwein, Barbara S. Schnierle.

Abstract:

A conceptual breakthrough in gene therapy would be gene transfer vector that could be systemically applied, allowing targeted gene transfer into a predetermined cell type. The host range of a retroviral vector is determined by the interaction of the viral envelope glycoprotein (Env) and the retrovirus receptor on the surface of the host cell. In this review, we describe the current efforts to engineer targeted envelope glycoproteins, which can be incorporated into retroviral particles and are capable of delivering genes in a highly specific manner.

Keywords: murine leukemia virus, targeting, vector, envelope, virus entry, host range

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2003
Page: [405 - 410]
Pages: 6
DOI: 10.2174/1566523034578267
Price: $58