Abstract
Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular remodeling and restenosis after angioplasty. Furthermore, recent studies have demonstrated that chemokines play an important role in the pathophysiology of acute coronary syndromes, post-infarction left ventricular remodeling and chronic heart failure. The capacity to control activation and movement of inflammatory cells suggests that chemokines and their receptors might provide novel targets for therapeutic intervention in a number of conditions characterized by chronic inflammation, including cardiovascular diseases. The present review summarizes current knowledge regarding the potential pathogenic role of chemokines in major cardiovascular disorders, as well as the modulation of the chemokine network as a novel, interesting therapeutic modality in this field.
Keywords: Chemokines, chemokine network, angioplasty, cardiovascular
Current Molecular Medicine
Title: Chemokines in Cardiovascular Remodeling: Clinical and Therapeutic Implications
Volume: 3 Issue: 2
Author(s): Gerasimos Filippatos, John T. Parissis, Stamatis Adamopoulos and Fotios Kardaras
Affiliation:
Keywords: Chemokines, chemokine network, angioplasty, cardiovascular
Abstract: Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular remodeling and restenosis after angioplasty. Furthermore, recent studies have demonstrated that chemokines play an important role in the pathophysiology of acute coronary syndromes, post-infarction left ventricular remodeling and chronic heart failure. The capacity to control activation and movement of inflammatory cells suggests that chemokines and their receptors might provide novel targets for therapeutic intervention in a number of conditions characterized by chronic inflammation, including cardiovascular diseases. The present review summarizes current knowledge regarding the potential pathogenic role of chemokines in major cardiovascular disorders, as well as the modulation of the chemokine network as a novel, interesting therapeutic modality in this field.
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Cite this article as:
Filippatos Gerasimos, Parissis T. John, Adamopoulos Stamatis and Kardaras Fotios, Chemokines in Cardiovascular Remodeling: Clinical and Therapeutic Implications, Current Molecular Medicine 2003; 3 (2) . https://dx.doi.org/10.2174/1566524033361546
DOI https://dx.doi.org/10.2174/1566524033361546 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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