Abstract
Borna Disease Virus (BDV) is a neurotropic RNA virus worldwide in distribution that causes movement, behavior or cognitive disorders in animal species. Borna Disease the illness ranges from asymptomatic to fatal meningoencephalitis across naturally infected warmblooded (mammalian and bird) species. There are also reported associations of the virus with neuropsychiatric diseases of man. Development of experimentally infected rodents, frequently rats, as models for examining behavioral, pharmacologic and biochemical responses to viral challenge at different stages of life have contributed to understanding the role of CNS viral injury in vulnerability to neurodevelopmental, behavioral and degenerative diseases.
Keywords: borna disease, virus, encephalitis, dopamine, serotonin, rat
Current Neuropharmacology
Title: Borna Disease Virus (BDV): Neuropharmacological Effects of a CNS Viral Infection
Volume: 1 Issue: 4
Author(s): Marylou V. Solbrig and George F. Koob
Affiliation:
Keywords: borna disease, virus, encephalitis, dopamine, serotonin, rat
Abstract: Borna Disease Virus (BDV) is a neurotropic RNA virus worldwide in distribution that causes movement, behavior or cognitive disorders in animal species. Borna Disease the illness ranges from asymptomatic to fatal meningoencephalitis across naturally infected warmblooded (mammalian and bird) species. There are also reported associations of the virus with neuropsychiatric diseases of man. Development of experimentally infected rodents, frequently rats, as models for examining behavioral, pharmacologic and biochemical responses to viral challenge at different stages of life have contributed to understanding the role of CNS viral injury in vulnerability to neurodevelopmental, behavioral and degenerative diseases.
Export Options
About this article
Cite this article as:
Solbrig V. Marylou and Koob F. George, Borna Disease Virus (BDV): Neuropharmacological Effects of a CNS Viral Infection, Current Neuropharmacology 2003; 1 (4) . https://dx.doi.org/10.2174/1570159033477035
DOI https://dx.doi.org/10.2174/1570159033477035 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
How to Get from Here to There: Macrophage Recruitment in Alzheimers Disease
Current Alzheimer Research Mitochondrial Calcium Signaling as a Therapeutic Target for Alzheimer’s Disease
Current Alzheimer Research Determination of Spatial and Temporal Distribution of Microglia by 230nm-High-Resolution, High-Throughput Automated Analysis Reveals Different Amyloid Plaque Populations in an APP/PS1 Mouse Model of Alzheimers Disease
Current Alzheimer Research Update on the Pharmacological Treatment of Alzheimers Disease
Current Neuropharmacology “Proposals for Amendments in the Diagnosis and Treatment of Encephalitis caused by Free-living Amoebae”
Infectious Disorders - Drug Targets Immunotherapy, Vascular Pathology, and Microhemorrhages in Transgenic Mice
CNS & Neurological Disorders - Drug Targets The Central Role of Angiotensin I-Converting Enzyme in Vertebrate Pathophysiology
Current Topics in Medicinal Chemistry Clinical Signs, Prevention and Treatment of Viral Infections in Infants
Infectious Disorders - Drug Targets Role of the APP Non-Amyloidogenic Signaling Pathway and Targeting α-Secretase as an Alternative Drug Target for Treatment of Alzheimers Disease
Current Medicinal Chemistry The Role of Amyloid-Beta Derived Diffusible Ligands (ADDLs) in Alzheimers Disease
Current Topics in Medicinal Chemistry The Effects of Soluble Aβ Oligomers on Neurodegeneration in Alzheimer's Disease
Current Pharmaceutical Design Vanutide Cridificar and the QS-21 Adjuvant in Japanese Subjects with Mild to Moderate Alzheimer’ s Disease: Results from Two Phase 2 Studies
Current Alzheimer Research The Widespread Anti-Protozoal Action of HIV Aspartic Peptidase Inhibitors: Focus on Plasmodium spp., Leishmania spp. and Trypanosoma cruzi
Current Topics in Medicinal Chemistry In Vivo DNA Electrotransfer for Immunotherapy of Cancer and Neurodegenerative Diseases
Current Drug Metabolism Pneumonia in Lung Transplant Recipients
Current Respiratory Medicine Reviews Structure Function Analysis of West Nile Virus RNA Dependent RNA Polymerase: Molecular Model and Implications for Drug Design
Medicinal Chemistry Retroperitoneal Cryptococcoma in a Case of Disseminated Cryptococcosis on Antifungal Maintenance Therapy
Current HIV Research Therapeutic Modulation of Cytokines in Chronic Infectious Diseases
Current Pharmaceutical Design Intracellular Amyloid β-Protein As a Therapeutic Target for Treating Alzheimers Disease
Current Alzheimer Research Editorial [Hot Topic:Active and Passive Aβ-Immunotherapy: Preclinical and Clinical Studies and Future Directions: Part I (Guest Editors: Michael G. Agadjanyan and David H. Cribbs)]
CNS & Neurological Disorders - Drug Targets