The Immunocompromised Host: Immune Alterations in Splenectomized Patients and Clinical Implications

Author(s): E. Jirillo, M. L. Mastronardi, M. Altamura, I. Munno, S. Miniello, G. Urgesi, L. Amati.

Journal Name: Current Pharmaceutical Design

Volume 9 , Issue 24 , 2003

Submit Manuscript
Submit Proposal

Abstract:

The spleen plays a paramount role in the host protection against invading microrganisms. In support of the above concept, in splenectomized patients there is increasing evidence of overwhelming postsplenectomy infections (OPSI). OPSI are caused by Streptococcus pneumoniae in about 80% of cases, but also Gram-negative bacteria are implicated in a certain number of cases. Therapeutically, penicillin and pneumococcal vaccines represent valid therapeutic approaches in Gram-positive OPSI. However, the effectiveness of polyvalent polysaccharide pneumococcal vaccines is still debated and, thus, other therapeutic strategies should be validated for combating OPSI. According to our personal data, a deficit of phagocytic activities and of T helper (h)-1 cells is very frequent in splenectomized patients. In sera, we found reduced levels of both Interferon-γ and Interleukin (IL)-4. These data are in accordance with the recent observation on the protective role of T cells against S. pneumoniae. In fact, patients deficient in IL-12 develop severe pneumococcal infections and undergo apoptosis of Th1 cells.

Keywords: lymphocytes, macrophages, spleen, t helper cells, vaccines

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 9
ISSUE: 24
Year: 2003
Page: [1918 - 1923]
Pages: 6
DOI: 10.2174/1381612033454306
Price: $58

Article Metrics

PDF: 6