Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Gene and Cancer Therapy - Pseudorabies Virus: A Novel Research and Therapeutic Tool?

Author(s): Zsolt Boldogkoi, Antal Nogradi.

Abstract:

The past decade has been marked by significant advances in the application of gene transfer into living cells of animals and humans, with the resulting catapulting of preclinical and basic scientific concepts into therapeutic trials. A variety of virus-mediated gene delivery techniques have proved to be superior to other methodologies. This article concisely reviews the current status of gene and tumor therapy, focusing on virus-based technologies, describes the molecular biology of neurotropic herpesviruses and the application of herpes simplex virus, a relative of pseudorabies virus (PRV) in gene transfer and cancer therapy protocols. Finally, it addresses the issue of whether PRV, a nonhuman pathogen, could serve as a suitable research and therapeutic tool as concerns genetic and tumor therapy.

Keywords: pseudorabies virus, herpes, hsv, gene transfer, gene therapy, tumor, cancer

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2003
Page: [155 - 182]
Pages: 28
DOI: 10.2174/1566523034578393
Price: $58