Microwave-Assisted Polymer-Supported Combinatorial Synthesis

Title: Microwave-Assisted Polymer-Supported Combinatorial Synthesis

Volume: 10 Issue: 22

Author(s): K. M.K. Swamy, Wen-Ben Yeh, Mei-Jung Lin and Chung-Ming Sun

Affiliation:

Keywords: microwave-assisted, polymer-supported, combinatorial synthesis, synthetic methodologies, combinatorial libraries, liquid phase combinatorial synthesis, polymer supported combinatorial synthesis

Abstract: Lead identification and optimization is always a challenge to the medicinal chemists in drug discovery. Numbers of simple to complex and smaller to bigger organic compounds are prepared to meet the screening purpose of biological targets. Conventional solution phase synthetic methodologies are lacking the speed to run along with the need of medicinally interesting compounds due to their long reaction time, tedious work-up and purification problems. Alternatively opted polymersupported synthesis of combinatorial libraries has been emerged as a promising tool in generating large numbers of structurally diverse molecules in a manner rapidand parallel. Microwave-assisted solid / liquid phase combinatorial synthetic techniques have been proved efficient in reducing the reaction time from days & hours to minutes & seconds and more promisingly to produce improved yields with high purities. This review briefs about the theory behind microwave chemical technology and glimpses of recent advancements in its application on polymer supported combinatorial synthesis.

Cite this article as:

Swamy M.K. K., Yeh Wen-Ben, Lin Mei-Jung and Sun Chung-Ming, Microwave-Assisted Polymer-Supported Combinatorial Synthesis, Current Medicinal Chemistry 2003; 10 (22) . https://dx.doi.org/10.2174/0929867033456594