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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
VOLUME: 9
ISSUE: 10
DOI: 10.2174/1381612033455323      Price:  $58









Insulin and the Blood-Brain Barrier

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Author(s): Stephen C. Woods, Randy J. Seeley, Denis G. Baskin and Michael W. Schwartz
Pages 795-800 (6)
Abstract:
Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions. Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition.
Keywords:
Insulin, Blood-Brain Barrier, homeostasis
Affiliation:
Department of Psychiatry, Box 670559, University of Cincinnati, Cincinnati, OH 45267-0559, USA