Phosphonomethoxyalkyl Analogs of Nucleotides

Author(s): Antonin Holy.

Journal Name: Current Pharmaceutical Design

Volume 9 , Issue 31 , 2003

Become EABM
Become Reviewer

Abstract:

Acyclic nucleoside phosphonates (ANP) are analogs of nucleotides exhibiting various biological (e.g. antiviral, cytostatic, antiparasitic, immunomodulatory) activities. This review describes synthetic approaches to their preparation, biological activities, structure-activity relationships and mode of action of ANPs, with emphasis to selected drugs or drug candidates. Three compounds of the ANP group (cidofovir, adefovir, tenofovir) are active components of potent antivirals approved for therapeutic use in human medicine aimed at hepatitis B, AIDS and various diseases caused by DNA viruses.

Keywords: adefovir, cidofovir, tenofovir, aids, hepatitis b, dna viruses, retroviruses

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 9
ISSUE: 31
Year: 2003
Page: [2567 - 2592]
Pages: 26
DOI: 10.2174/1381612033453668
Price: $58

Article Metrics

PDF: 7