Function and Regulation of Tumor Necrosis Factor Receptor Type 2

Author(s): I. Carpentier , B. Coornaert , R. Beyaert .

Journal Name: Current Medicinal Chemistry

Volume 11 , Issue 16 , 2004

Abstract:

TNF is a major proinflammatory cytokine, which exerts its effects through two different receptors known as TNF-R1 and TNF-R2. Whereas TNF-R1 induced signaling pathways have been very well characterized during the past years, TNF-R2 has been much less well studied. Nevertheless, the function of TNF-R2 should not be underestimated, the more because this receptor shows a much more restricted but inducible expression. Several inflammatory diseases and cancers show upregulated levels of soluble TNF-R2 or are associated with TNF-R2 polymorphisms, implicating an important role for TNF-R2 as a therapeutic target. Here we will review the mechanisms that regulate TNF-R2 expression, as well as discuss TNF-R2 induced signal transduction and cross-talk with TNF-R1.

Keywords: tumor necrosis factor receptor (tnf-r), signal transduction, apoptosis, inflammation, cd120b, disease, polymorphisms

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Article Details

VOLUME: 11
ISSUE: 16
Year: 2004
Page: [2205 - 2212]
Pages: 8
DOI: 10.2174/0929867043364694
Price: $58

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