Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE


Mechanisms of Phospholipase C-Regulated Calcium Entry

Author(s): Gary S. Bird, Omar Aziz, Jean-Philippe Lievremont, Barbara J. Wedel, Mohamed Trebak, Guillermo Vazquez and James W. Putney Jr.

Affiliation: NIEHS, P.O. Box 12233,Research Triangle Park, NC 27709., USA.


In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, storeoperated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.

Keywords: phospholipase c, phospholipase c-linked receptors, intracellular

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Article Details

Page: [291 - 301]
Pages: 11
DOI: 10.2174/1566524043360681
Price: $58