Mechanisms of Phospholipase C-Regulated Calcium Entry
Gary S. Bird, Omar Aziz, Jean-Philippe Lievremont, Barbara J. Wedel, Mohamed Trebak, Guillermo Vazquez and James W. Putney Jr.
Affiliation: NIEHS, P.O. Box 12233,Research Triangle Park, NC 27709., USA.
In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, storeoperated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.
Keywords: phospholipase c, phospholipase c-linked receptors, intracellular
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