Abstract
Since late 1950s the main strategies to treat cancer, besides surgery, have been radiotherapy or chemotherapy. These approaches work primarily by damaging proliferating cells at the level of DNA replication or cell division, and inducing apoptotic cell suicide as a secondary response to the damage. In recent years, efforts to improve cancer therapy have focused on the development of more selective, biological mechanism based approaches that can help to overcome tumor resistance as well as minimize toxic side effects. In the present review new strategies and new targets for biological cancer therapy will be discussed. In particular, new angiogenic pathways discovered in melanoma will be discussed in relationship to a more efficient anticancer strategy. In summary, this review tries to identify the most logical targets and the most useful mechanisms of tumor inhibition in light of new knowledge from the basic research including human genome project.
Keywords: apoptosis, angiogenesis, vasculogenic mimicry
Current Drug Targets
Title: Cellular Targets for Anticancer Strategies
Volume: 5 Issue: 4
Author(s): Caterina A.M. La Porta
Affiliation:
Keywords: apoptosis, angiogenesis, vasculogenic mimicry
Abstract: Since late 1950s the main strategies to treat cancer, besides surgery, have been radiotherapy or chemotherapy. These approaches work primarily by damaging proliferating cells at the level of DNA replication or cell division, and inducing apoptotic cell suicide as a secondary response to the damage. In recent years, efforts to improve cancer therapy have focused on the development of more selective, biological mechanism based approaches that can help to overcome tumor resistance as well as minimize toxic side effects. In the present review new strategies and new targets for biological cancer therapy will be discussed. In particular, new angiogenic pathways discovered in melanoma will be discussed in relationship to a more efficient anticancer strategy. In summary, this review tries to identify the most logical targets and the most useful mechanisms of tumor inhibition in light of new knowledge from the basic research including human genome project.
Export Options
About this article
Cite this article as:
La Porta A.M. Caterina, Cellular Targets for Anticancer Strategies, Current Drug Targets 2004; 5 (4) . https://dx.doi.org/10.2174/1389450043345434
DOI https://dx.doi.org/10.2174/1389450043345434 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synergistic Effect of Combined HIV/HCV Immunogens: A Combined HIV-1/HCV Candidate Vaccine Induces a Higher Level of CD8+ T Cell-Immune Responses in HLA-A2.1 Mice
Current HIV Research MAVS: A New Weapon in the Fight Against Viral Infections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Advances in Translational Pharmacological Investigations in Identifying and Validating Molecular Targets of Natural Product Anticancer Agents
Current Cancer Drug Targets Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function
Current Genomics Birt-Hogg-Dubé Syndrome, a Genodermatosis that Increases Risk for Renal Carcinoma
Current Molecular Medicine Melatonin, a Potential Therapeutic Agent for Smooth Muscle-Related Pathological Conditions and Aging
Current Medicinal Chemistry Novel Molecular-Targeted Therapeutics for the Treatment of Cancer
Anti-Cancer Agents in Medicinal Chemistry Editorial (Thematic Issue: Mitochondria in Human Diseases and Animal Evolution)
Current Molecular Medicine Kefir: A Synbiotic with Approved Anticarcinogenic Properties
Current Bioactive Compounds Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging
Anti-Cancer Agents in Medicinal Chemistry Regulation of Cell Migration and Invasion by Specific Modules of uPA: Mechanistic Insights and Specific Inhibitors
Current Drug Targets Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives
Current Topics in Medicinal Chemistry A New Approach for Cancer Immunotherapy Based on the Cancer Stem Cell Antigens Properties
Current Molecular Medicine Salidroside - Can it be a Multifunctional Drug?
Current Drug Metabolism Current Perspectives on Anti-Aging Interventions
Letters in Drug Design & Discovery CXCL8 as a Potential Therapeutic Target for HIV-Associated Neurocognitive Disorders
Current Drug Targets Gastrointestinal Non Colorectal Cancer. Do Elderly Patients Need a Specific Management?
Anti-Cancer Agents in Medicinal Chemistry Regulation of the PI3K-Akt Network: Current Status and a Promise for the Treatment of Human Diseases
Current Signal Transduction Therapy Signaling Pathways Responsible for Cancer Cell Invasion as Targets for Cancer Therapy
Current Cancer Drug Targets A Prooxidant Mechanism for the Anticancer and Chemopreventive Properties of Plant Polyphenols
Current Drug Targets