β-Sheet Breakers for Alzheimers Disease Therapy

Author(s): Bieler S., Soto C..

Journal Name:Current Drug Targets

Volume 5 , Issue 6 , 2004

Abstract:

A growing wealth of evidence indicates that the key pathological event in Alzheimers disease is the conversion of the normal soluble amyloid-β peptide into β-sheet-rich oligomeric structures which have a neurotoxic activity and ability to form insoluble amyloid deposits that accumulate in the brain. b-sheet breakers constitute a new class of drugs that are designed to specifically bind amyloid-β peptide and block and / or reverse this abnormal conformational change. In this article we review this approach, describe diverse compounds reported to have this activity and summarize the data supporting the view that b-sheet breakers could be serious candidates to combat this devastating disease.

Keywords: alzheimer disease, amyloid, therapy

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2004
Page: [553 - 558]
Pages: 6
DOI: 10.2174/1389450043345290
Price: $58

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