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Current Drug Targets
ISSN (Print): 1389-4501
ISSN (Online): 1873-5592
VOLUME: 5
ISSUE: 6
DOI: 10.2174/1389450043345290      Price:  $58









β-Sheet Breakers for Alzheimers Disease Therapy

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Author(s): Bieler S. and Soto C.
Pages 553-558 (6)
Abstract:
A growing wealth of evidence indicates that the key pathological event in Alzheimers disease is the conversion of the normal soluble amyloid-β peptide into β-sheet-rich oligomeric structures which have a neurotoxic activity and ability to form insoluble amyloid deposits that accumulate in the brain. b-sheet breakers constitute a new class of drugs that are designed to specifically bind amyloid-β peptide and block and / or reverse this abnormal conformational change. In this article we review this approach, describe diverse compounds reported to have this activity and summarize the data supporting the view that b-sheet breakers could be serious candidates to combat this devastating disease.
Keywords:
alzheimer disease, amyloid, therapy
Affiliation:
Protein Misfolding Disorders Laboratory, Department of Neurology, University of Texas Medical Branch,Galveston, TX, USA