Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Cytokines in Neuroinflammation and Alzheimers Disease

Author(s): Mathias Cacquevel, Nathalie Lebeurrier, Simon Cheenne, Denis Vivien.

Abstract:

Inflammation has been reported in numerous neurodegenerative disorders such as Parkinsons disease, stroke and Alzheimers disease (AD). In AD, the inflammatory response is mainly located to the vicinity of amyloid plaques. Cytokines, such as Interleukin-1 (IL-1), Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and Transforming Growth Factor beta (TGF-β) have been clearly involved in this inflammatory process. Although their expression is induced by the presence of amyloid-beta peptide, these cytokines are also able to promote the accumulation of amyloidbeta peptide. Altogether, IL-1, IL-6, TNF-α and TGF-β should be considered as key players of a vicious circle leading to the progression of the disease.

Keywords: alzheimer disease, inflammation, cytokine

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2004
Page: [529 - 534]
Pages: 6
DOI: 10.2174/1389450043345308
Price: $58