Importance of Aquaporins in the Physiopathology of Brain Edema

Author(s): Jose L. Venero, Alberto Machado, Josefina Cano.

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 18 , 2004

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Abstract:

Aquaporins (AQPs) are water channels that mediate the efficient movement of water across the membrane. Among different AQPs, AQP4 is the predominant water channel in the brain and is thought to play a significant role in the physiopathology of brain edema. Brain edema is a major clinical problem since it largely accounts for the cause of death in patients suffering from traumatic brain injury or cerebrovascular accidents. In this review, we have tried to summarize comprehensive information about the pathological events conducting to brain edema. In addition, we also have summarized active investigation in the field of AQPs and cerebral edema to find plausible explanations and to deduce potential future directions for the treatment of this clinical condition.

Keywords: aquaporin, edema, traumatic brain injury, hypoxia, blood brain barrier

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Article Details

VOLUME: 10
ISSUE: 18
Year: 2004
Page: [2153 - 2161]
Pages: 9
DOI: 10.2174/1381612043384150
Price: $58

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