Abstract
Stroke,is the third leading cause of death and disability in the Western world.Stroke refers to set of ischemic conditions resulting from the occlusion or hemorrhage of blood vessels supplying the brain.Loss of blood flow to the brain results in neuronal injury due to both oxygen and nutrient deprivation and the activation of injurious signal cascades.Ultimately cerebral ischemia results in death and dysfunction of brain cells,and neurological deficits that reflect the location and size of the compromised brain area.Injury due to ischemic stroke occurs by a highly choreographed series of complex spatial and temporal events that evolve over hours to days.These events involve complex interactions between fundamental cell injury mechanisms including excitotoxicity and ionic imbalance, oxidative and nitrosative stress,apoptotic-like cell death and inflammatory responses.Genetically engineered mice have been valuable tools to probe putative mechanisms of neuronal death and uncover potential strategies that might render neurons resistant to ischemic injury.Findings from experimental stroke studies in genetically engineered animals are discussed.
Keywords: Ischemic Injury, apoptotic, hemorrhage, nitrosative
Current Molecular Medicine
Title: What have Genetically Engineered Mice Taught Us About Ischemic Injury?
Volume: 4 Issue: 2
Author(s): Dong Liang, Ted M. Dawson and Valina L. Dawson
Affiliation:
Keywords: Ischemic Injury, apoptotic, hemorrhage, nitrosative
Abstract: Stroke,is the third leading cause of death and disability in the Western world.Stroke refers to set of ischemic conditions resulting from the occlusion or hemorrhage of blood vessels supplying the brain.Loss of blood flow to the brain results in neuronal injury due to both oxygen and nutrient deprivation and the activation of injurious signal cascades.Ultimately cerebral ischemia results in death and dysfunction of brain cells,and neurological deficits that reflect the location and size of the compromised brain area.Injury due to ischemic stroke occurs by a highly choreographed series of complex spatial and temporal events that evolve over hours to days.These events involve complex interactions between fundamental cell injury mechanisms including excitotoxicity and ionic imbalance, oxidative and nitrosative stress,apoptotic-like cell death and inflammatory responses.Genetically engineered mice have been valuable tools to probe putative mechanisms of neuronal death and uncover potential strategies that might render neurons resistant to ischemic injury.Findings from experimental stroke studies in genetically engineered animals are discussed.
Export Options
About this article
Cite this article as:
Liang Dong, Dawson M. Ted and Dawson L. Valina, What have Genetically Engineered Mice Taught Us About Ischemic Injury?, Current Molecular Medicine 2004; 4 (2) . https://dx.doi.org/10.2174/1566524043479194
DOI https://dx.doi.org/10.2174/1566524043479194 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Mechanisms Involved in the Control of Neurohypophyseal Hormones Secretion
Current Pharmaceutical Design Myocardial Infarction after Rituximab Treatment for Rheumatoid Arthritis: Is there a Link?
Current Pharmaceutical Design Does Fluid Administration Based on Fluid Responsiveness Tests such as Passive Leg Raising Improve Outcomes in Sepsis?
Current Cardiology Reviews Painful Peripheral Neuropathies
Current Neuropharmacology Impact of Ultrasound Contrast Agents in Echocardiographic Assessment of Ischemic Heart Disease
Recent Patents on Cardiovascular Drug Discovery Mechanisms of Cortical Neural Synchronization Related to Healthy and Impaired Consciousness: Evidence by Quantitative Electroencephalographic Studies
Current Pharmaceutical Design Synthesis of Novel Test Compounds for Antiviral Chemotherapy of Severe Acute Respiratory Syndrome (SARS)
Current Medicinal Chemistry HIF Prolyl-4-hydroxylase Interacting Proteins: Consequences for Drug Targeting
Current Pharmaceutical Design Cardio-Vascular Risks Associated with Clozapine Treatment
Current Psychiatry Reviews Immune Response and Immunotherapy: Live Attenuated Listeria monocytogenes (Lm)-LLO Immunotherapy for the Treatment of Prostate Cancer
Current Cancer Therapy Reviews Levosimendan: A Novel Agent in Heart Failure
Recent Patents on Cardiovascular Drug Discovery Obesity, Metabolic Syndrome, Diabetes and Arterial Hypertension
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Recent Trends on the Use of Nanoparticles for Nitric Oxide Delivery in Antimicrobial Applications
Drug Delivery Letters Current Developments in the Therapeutic Potential of S-Nitrosoglutathione, an Endogenous NO-Donor Molecule
Current Pharmaceutical Biotechnology Pathophysiology of Sepsis and Recent Patents on the Diagnosis, Treatment and Prophylaxis for Sepsis
Recent Patents on Inflammation & Allergy Drug Discovery Safety and Efficacy of Aliskiren in the Treatment of Hypertension and Associated Clinical Conditions
Current Drug Safety The Role of the Endothelium in Premature Atherosclerosis: Molecular Mechanisms
Current Medicinal Chemistry PF-04886847 (an Inhibitor of Plasma Kallikrein) Attenuates Inflammatory Mediators and Activation of Blood Coagulation in Rat Model of Lipopolysaccharide (LPS) - Induced Sepsis
Cardiovascular & Hematological Agents in Medicinal Chemistry Enhanced Anticancer Activity and Apoptosis Effect of Bioactive Compound Quercetin Extracted from <i>Ocimum sanctum</i> Leaves
Current Nanomedicine Vasopressin and Terlipressin in Neonates and Children with Refractory Septic Shock
Current Drug Metabolism