Creating Chemical Diversity to Target Protein Kinases

Author(s): B. Li, Y. Liu, T. Uno, N. Gray.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 7 , Issue 5 , 2004

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Abstract:

Protein kinases play crucial roles in regulating virtually every cellular process and are currently attracting tremendous interest as drug targets from the pharmaceutical industry. The major challenges facing the development of the potential kinase inhibitor drugs are: selectivity, physical properties (solubility, molecular weight), and pharmacological properties (bioavailability, half life, toxicity, etc.) This review focuses on how selective protein kinase inhibitors that target the ATP and allosteric binding sites are currently being identified and optimized.

Keywords: kinase inhibitors, protein kinases, protein phosphorylation, signal transduction, kinase-targeted libraries, anticancer drugs, anti-inflammatory drugs

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2004
Page: [453 - 472]
Pages: 20
DOI: 10.2174/1386207043328580
Price: $58

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