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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Lithiated α-Chloroalkylheterocycles: Utility in Synthetic Organic Chemistry

Author(s): Saverio Florio, Vito Capriati and Renzo Luisi

Volume 8, Issue 16, 2004

Page: [1529 - 1545] Pages: 17

DOI: 10.2174/1385272043369719

Price: $65

Abstract

The chemistry of lithiated α-chloroalkylheterocycles such as α-chloroalkylbenzothiazoles, - benzotriazoles, -pyridines, -triazines, -thiazoles and -oxazolines has been reviewed. The synthetic application of this kind of chemistry for the stereoselective preparation of heteroaryl cyclopropanes, oxiranes, aziridines, alkenes and functionalised nitroarenes through a Darzens-type reaction, has been especially emphasised.

Keywords: carbenoids, haloalkyllithiums, chemistry, reagents, reactions, ring expansion, heterocyclic ring

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