Targeting the Chemokine Receptor CXCR3 and Its Ligand CXCL10 in the Central Nervous System: Potential Therapy for Inflammatory Demyelinating Disease?

Author(s): Torben Lykke Sørensen.

Journal Name: Current Neurovascular Research

Volume 1 , Issue 2 , 2004

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Abstract:

Multiple sclerosis is an inflammatory disease of the CNS and a leading cause of disability. Inflammatory mediators play an orchestrating part in lesional development leading to symptoms. Chemokines -chemoattractant cytokines - regulate the inflammatory composite of the MS lesion. This review focuses on the present data regarding CXCL10 (previously known as IP-10) and CXRC3 in multiple sclerosis, since consistent data has suggested that this chemokine/chemokine receptor pair has a pivotal role in leukocyte recruitment into the central nervous system (CNS) in multiple sclerosis.

Keywords: chemokines, chemokine receptors, multiple sclerosis

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [183 - 190]
Pages: 8
DOI: 10.2174/1567202043480143
Price: $58

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