Circular dichroism spectroscopy based on exciton coupling (ECCD) is a powerful tool for stereochemical analysis of organic compounds, i.e. for the determination of absolute configuration as well as conformation. Although the method is widely used for more than three decades, only in the past decade advances have been made toward making the ECCD method more sensitive and user-friendly. The newly developed extended π-conjugated chromophores with high molecular extinction coefficient (ε > 105) allow to make CD measurements with less than 0.1 mg amounts of the analyte. Furthermore, tailor-made chromophoric derivatives allow unobstructed CD measurements in a chosen spectral window extending well into the visible region. In addition, chromophore can now be attached to the analyzed molecule without resorting to the formation of a covalent bond between the functional group of an analyte and the chromophoric molecule. These and other applications, preceded by a short introduction describing foundations of the ECCD method, are covered by the review. This review is dedicated to Professor Maciej Wiewiorowski on the occasion of his 85th birthday and in recognition of his contribution to the field of natural products chemistry.