Current Drug Delivery

Istvan Toth
School of Pharmacy,University of Queensland
Brisbane, 4072
Australia

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HIV-1 Vpr: Enhancing Sensitivity of Tumors to Apoptosis

Author(s): Karuppiah Muthumani, Andrew Y. Choo, Daniel S. Hwang, Kenneth E. Ugen, David B. Weiner.

Abstract:

Cancers can adapt several evasive functions including apoptosis evasion, self-sufficiency in growth signals, insensitivity to anti-growth signals, sustained angiogenesis, limitless replication potential, tissue invasion and metastasis. The invariable hurdle for development of therapies against such aberrant conditions requires both selective and potent cytotoxicity. Analysis of HIV-1 Vprs apoptotic and anti-proliferative activity have revealed potentially important implications for cancer therapy. Accordingly, we have reviewed the properties of Vpr that will likely contribute to its efficacious function as an anti-tumor agent. Among these are its ability to induce cell cycle arrest, inhibit inflammation, provoke p53 independent apoptosis, and selective killing of rapidly dividing cells.

Keywords: hiv-1, vpr, nf-kappab, p53, mitochondria, cancer, caspase and apoptosis

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2004
Page: [335 - 344]
Pages: 10
DOI: 10.2174/1567201043334614
Price: $58