Activated MR Contrast Agents

Author(s): Mark P. Lowe.

Journal Name: Current Pharmaceutical Biotechnology

Volume 5 , Issue 6 , 2004

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Abstract:

The relative non-specificity of the first generation MR contrast agents has meant that a new approach to their design is required. This review focuses on a new class of more specific or functional agents. These are the so-called “activated”, “smart” or “responsive” contrast agents. The relaxivity of an activated contrast agent is responsive to (or can be modulated by) a particular in vivo stimulus such as a change in biological environment or activity. More specifically, a “switching on” of contrast in response to an event such as a change in physiological pH, metal ion concentration, enzyme activity or partial pressure of oxygen is sought. The current generation of activated MR contrast agents is discussed herein.

Keywords: oxygen, MR Contrast Agents

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2004
Page: [519 - 528]
Pages: 10
DOI: 10.2174/1389201043376562
Price: $58

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