Abstract
The budding yeast Saccharomyces cerevisiae has been one of the premier models for the study of eukaryote molecular biology for over 50 years. These studies have revealed a complex and robust yeast phenome and elucidated many of the underlying principles common to all eukaryotes including DNA, RNA, protein and metabolite interaction networks. However the degree complexity and integration of the cellular network has made dissecting the temporal dynamics of the phenotype a rather daunting task. Here I review work on glycolytic oscillation, oscillation observed in continuous culture and colony pattern formation, and find that redox is a central thread underpinning these phenomena. The outputs of the systems involve sub-networks that are at the core of the cellular network, e.g., glycolysis, stress response, respiration, cell cycle, amino acid biosynthesis, leading to the conclusion that a fundamental redox attractor underpins these core cellular processes.
Keywords: Saccharomyces cerevisae, phenotype, glycolytic, oscillation
Current Genomics
Title: On the Temporal Self-Organisation of Saccharomyces cerevisae
Volume: 5 Issue: 8
Author(s): Douglas B. Murray
Affiliation:
Keywords: Saccharomyces cerevisae, phenotype, glycolytic, oscillation
Abstract: The budding yeast Saccharomyces cerevisiae has been one of the premier models for the study of eukaryote molecular biology for over 50 years. These studies have revealed a complex and robust yeast phenome and elucidated many of the underlying principles common to all eukaryotes including DNA, RNA, protein and metabolite interaction networks. However the degree complexity and integration of the cellular network has made dissecting the temporal dynamics of the phenotype a rather daunting task. Here I review work on glycolytic oscillation, oscillation observed in continuous culture and colony pattern formation, and find that redox is a central thread underpinning these phenomena. The outputs of the systems involve sub-networks that are at the core of the cellular network, e.g., glycolysis, stress response, respiration, cell cycle, amino acid biosynthesis, leading to the conclusion that a fundamental redox attractor underpins these core cellular processes.
Export Options
About this article
Cite this article as:
Murray B. Douglas, On the Temporal Self-Organisation of Saccharomyces cerevisae, Current Genomics 2004; 5 (8) . https://dx.doi.org/10.2174/1389202043348580
DOI https://dx.doi.org/10.2174/1389202043348580 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Drugs in Newborn Resuscitation: The More We Learn the Least We Use
Current Medicinal Chemistry Fenofibrate: Metabolic and Pleiotropic Effects
Current Vascular Pharmacology Natural Cures for Type 1 Diabetes: A Review of Phytochemicals, Biological Actions, and Clinical Potential
Current Medicinal Chemistry Recombinant Protein Based Therapeutics for IPF
Inflammation & Allergy - Drug Targets (Discontinued) Antagonism of Endothelin (ETA and ETB) Receptors During Renovascular Hypertension-Induced Vascular Dementia Improves Cognition
Current Neurovascular Research Bortezomib in the Treatment of Cancer
Recent Patents on Anti-Cancer Drug Discovery Back to (non-)Basics: An Update on Neutral and Charge-Balanced Glycosidase Inhibitors
Mini-Reviews in Medicinal Chemistry Compared Chemical Activity and Effects on Cell Viability of Various Antioxidant Compounds
Current Analytical Chemistry Subject Index To Volume 3
Current Genomics 11 Years of Cyanopyrrolidines as DPP-IV Inhibitors
Current Topics in Medicinal Chemistry In Vitro and In Vivo Performance of Novel Spray Dried Andrographolide Loaded Scleroglucan Based Formulation for Dry Powder Inhaler
Current Drug Delivery How to Assess Sympathetic Nervous System Activity in Clinical Practice
Current Clinical Pharmacology Targeting the AMP-Activated Protein Kinase for the Treatment of Type 2 Diabetes
Current Drug Targets - Immune, Endocrine & Metabolic Disorders <i>Terminalia catappa</i> Fruit Extract Reverses Streptozotocin-Induced Diabetic Retinopathy in Rats
Endocrine, Metabolic & Immune Disorders - Drug Targets GLUT4 Traffic: Perspectives from Cultured Muscle Cells
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents The Novel Antipsychotic Cariprazine (RGH-188): State-of-the-Art in the Treatment of Psychiatric Disorders
Current Pharmaceutical Design Dietary Lipids and Alzheimer’s Disease
Current Alzheimer Research From Gastroprotective to Ulcerogenic Effects of Glucocorticoids: Role of Long-Term Glucocorticoid Action
Current Pharmaceutical Design Thiomers, Mucoadhesion and Oral Delivery of Biomacromolecules
Current Drug Therapy Bis-Quinolinium Cyclophanes: Highly Potent and Selective Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel
Current Medicinal Chemistry