Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106


Vitamin E Analogues: A New Class of Inducers of Apoptosis with Selective Anti-Cancer Effects

Author(s): Jiri Neuzil, Marco Tomasetti, Albert S. Mellick, Renata Alleva, Brian A. Salvatore, Marc Birringer, Marc W. Fariss.


In spite of unrelenting effort, the net incidence of neoplastic diseases appears not to have been curbed. While some types of cancer have been suppressed significantly, others are either stagnating or on the increase. Therefore, the need for a cure is imperative, in particularly a drug or combination of drugs that would be selective for malignant cells, i.e. with as low secondary toxicity as possible. Recent data strongly suggest that analogues of vitamin E, epitomised by the most studied α-tocopheryl succinate (α-TOS), may meet the need for the coveted drugs with a selective anti-neoplastic effect. The reasons for this optimism are reviewed in this article.

Keywords: vitamin e analogues, inducers of apoptosis, neoplastic diseases, anti-neoplastic

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Article Details

Year: 2004
Page: [355 - 372]
Pages: 18
DOI: 10.2174/1568009043332943
Price: $58