Recent Developments in the Chemistry of Potassium Channel Activators: The Cromakalim Analogs

Author(s): S. Sebille, P. de Tullio, S. Boverie, M. H. Antoine, P. Lebrun, B. Pirotte.

Journal Name: Current Medicinal Chemistry

Volume 11 , Issue 9 , 2004


Potassium channels play a crucial role in controlling the cell membrane potential. Among the different varieties of K+ channels, the ATP-sensitive potassium channels (KATP channels) have been characterized in numerous cell types, such as skeletal and smooth muscle cells, endocrine cells, cardiac cells and central neurons. Several molecules are known to activate KATP channels and have been named “potassium channel openers” (PCOs). Such compounds may have a wide therapeutic potential and a few drugs are currently used as antihypertensive agents. Different chemical series of PCOs have been explored. This heterogeneous group of organic compounds comprises the benzopyran series including potent vasorelaxant drugs, such as cromakalim. The latter compound, a typical example of potassium channel opener, exerts its biological effect by activating KATP channels. This review presents recent developments in the chemistry of cromakalim analoges and reports chemical aspects governing their potency and tissue selectivity.

Keywords: cromakalim, benzopyran, katp channel, potassium channel openers

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Article Details

Year: 2004
Page: [1213 - 1222]
Pages: 10
DOI: 10.2174/0929867043365378
Price: $58

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