Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Monoamine Oxidases: Certainties and Uncertainties

Author(s): Keith F. Tipton, Sinead Boyce, Jeff O'Sullivan, Gavin P. Davey and Joe Healy

Affiliation: Department of Biochemistry, Trinity College, Dublin 2, Ireland

Keywords: monoamine oxidases, substrates, inhibitors

Abstract:

A great deal has been learned about the behaviour of monoamine oxidase in the 75 years since it was first discovered, but there is still a great deal left to understand. This review concentrates on the dynamic aspects of our knowledge of the interactions of MAO with substrates and inhibitors and how it may collaborate with other enzymes, with particular emphasis on aspects that remain to be clarified.

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Article Details

VOLUME: 11
ISSUE: 15
Page: [1965 - 1982]
Pages: 18
DOI: 10.2174/0929867043364810