Functional Neurochemistry of Alzheimers Disease

Author(s): Wieland Gsell, Gerd Jungkunz, Peter Riederer.

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 3 , 2004

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Abstract:

A review of neurochemical research on classical neurotransmitters, i.e. acetylcholine, serotonin, noradrenaline, dopamine, glutamate, and GABA in Alzheimers disease is presented. Findings are linked to the information processing system of the human brain to establish a more functional neurochemistry. On this basis, different pharmacotherapeutic strategies are discussed. Our conclusion is that current symptomatic therapy of Alzheimers disease is insufficient. Besides therapy with acetylcholineesterase inhibitors, comedication to act on imbalances between serotonin and noradrenaline on the one site, and dopamine, glutamate and GABA on the other site should should be considered.

Keywords: Neurochemistry, acetylcholineesterase, serotonin, dopamine, glutamate, GABA, noradrenaline

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2004
Page: [265 - 293]
Pages: 29
DOI: 10.2174/1381612043386473
Price: $58

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