SNC 80 and Related δ Opioid Agonists

Author(s): S. N. Calderon, A. Coop.

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 7 , 2004

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Abstract:

The discovery of the selective delta (δ) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of δ-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based d opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.

Keywords: diarylmethylpiperazine, BW373U86

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Article Details

VOLUME: 10
ISSUE: 7
Year: 2004
Page: [733 - 742]
Pages: 10
DOI: 10.2174/1381612043453054
Price: $58

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