α-Galactosylceramide: Potential Immunomodulatory Activity and Future Application [General Articles]

Author(s): Yoshihiro Hayakawa, Dale I. Godfrey, Mark J. Smyth.

Journal Name:Current Medicinal Chemistry

Volume 11 , Issue 2 , 2004

Abstract:

α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. γ-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-α and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α- GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.

Keywords: Galactosylceramide, immunomodulatory, GalCer

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2004
Page: [241 - 252]
Pages: 12
DOI: 10.2174/0929867043456115
Price: $58