The Macrolide Antibiotics: A Pharmacokinetic and Pharmacodynamic Overview

Author(s): R. Jain, L. H. Danziger.

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 25 , 2004

Abstract:

The macrolide antimicrobial family is a comprised of 14, 15 and 16 member-ringed compounds that are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. The macrolides accumulate in many tissues such as the epithelial lining fluid and easily enter the host defense cells, predominantly macrophages and polymorphonuclear leukocytes (PMNs). Concentrations of the macrolides in respiratory tract tissues and extracellular fluids are in almost all cases higher than simultaneously measured serum concentrations, making them useful for respiratory tract infections. This review will focus on pharmacokinetic and pharmacodynamic aspects of the clinical relevant macrolides including azithromycin, clarithromycin, dirithromycin, erythromycin and roxithromycin.

Keywords: macrolides, pharmacokinetic, pharmacodynamic, clarithromycin, azithromycin, roxithromycin, dirithromycin, erythromycin

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Article Details

VOLUME: 10
ISSUE: 25
Year: 2004
Page: [3045 - 3053]
Pages: 9
DOI: 10.2174/1381612043383322
Price: $58

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