Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Vaccine Development for Group A Streptococcus Infections and Associated Diseases

Author(s): M. R. Batzloff, K. S. Sriprakash and M. F. Good

Affiliation: The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane QLD 4029,Australia.

Keywords: Streptococcus, pharyngitis


Group A streptococcus (GAS) is responsible for a number of diseases ranging from uncomplicated pharyngitis through to life-treating invasive and post-infectious diseases such as necrotizing fasciitis and rheumatic heart disease. GAS associated diseases occur globally and are serious problems in many developing nations and indigenous populations of many developed nations. This, and the resurgence in industrialized countries, and increased virulence of GAS in the 1980s highlight the need of cost-effective control strategies. Here we highlight the GAS diseases that are still a problem in many populations and discuss potentially useful strategies to combat GAS infections and disease.

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Article Details

Page: [57 - 69]
Pages: 13
DOI: 10.2174/1389450043490721